Principal Scientist, Medicinal Chemistry

Our Culture:
Our Culture: Why work with us?
At Foghorn Therapeutics, we believe in “People First, Mission Always.”
We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.
We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.
Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.
Our Science:
The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.
Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.
The Role:
This role is an opportunity to help advance our portfolio of drug discovery projects through the design and synthesis of new chemical entities as a part of the Medicinal Chemistry Team. You will work as part of multidisciplinary teams from early discovery to the delivery of drug candidates. We have 3 world class science labs onsite. A lot of the scientific work you’re doing in this role will be lab based. At Foghorn there is opportunity to advance your career and grow within our organization.
In This Role, You’ll Get To:
Design, plan and execute multi-step organic synthesis and purification of high-quality target molecules and solve synthetic chemistry challenges to enable expansion of available chemical space
Analyze data sets and develop SAR using in-house and commercial in silico tools and communicate results in formal and informal settings
Proactively seek input from computational chemistry and structural biology to collaboratively work through iterative design processes to generate novel design ideas
Partner with CROs to enable timely delivery of target compounds
Requirements
Qualifications and skills
MS or PhD degree in organic chemistry, in addition to 5+ years of medicinal chemistry experience in a pharmaceutical / biotechnology setting OR;
BS degree in organic chemistry, in addition to 12+ years of medicinal chemistry experience in a pharmaceutical / biotechnology setting
Industry experience in Oncology
Work experience in medicinal chemistry with PROTACs, degraders and beyond-rule-of-five molecules
High levels of competence in all aspects of modern synthetic chemistry, including single compound synthesis, small parallel arrays, purification methods and analytical characterization
Significant experience and successful implementation of independent synthetic route design and problem solving
Familiarity with a variety of biochemical, biophysical, and cellular assays and ability to interpret data derived from such assays
Understanding of correlations between compound structure, properties, and ADME and ability to optimize multiple parameters
Proven ability to work well with others in a dynamic and highly collaborative environment
Excellent communication skills are required, particularly the ability to effectively present work and ideas and contribute to team discussions.
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
BCBS PPO and PPO HSA plans
BCBS Dental Plan
EyeMed Vision Plan
FSA and HSA for medical expenses and dependent care expenses
Free premium access to fitness, nutrition, and mindfulness classes
Unlimited paid time off policy
Discretionary winter shut down
Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Free parking or subsidized commuter passes
Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Health Care Plan (Medical, Dental & Vision)
Retirement Plan (401k with the company match)
Life Insurance (Basic, Voluntary & AD&D)
Unlimited Paid Time Off Policy
Family Leave (12 weeks for primary caregiver/ birthing parent, 3 weeks for non-primary caregiver)
Short Term & Long-Term Disability
Training & Development
Work From Home
Free Snacks and Company Lunches on Wednesdays
Wellness Resources
Stock Option Plan